ABSTRACT
Background: Bilateral Superficial cervical plexus block (BSCPB) is one method of post op analgesia given before General anesthesia as this avoids polypharmacy. Objectives: This prospective randomized, controlled clinical study compared the post-operative analgesic efficacy of BSCPB using Ropivacaine (0.5%) with or without Clonidine (2mcg/kg).It also evaluated the intra operative opioid dosage and hemodynamic responses in patients undergoing thyroid surgeries. Methods: 60 Patients undergoing thyroidectomy were randomized into 3 groups,(Group A) BSCPB using normal saline ,(group B)Ropivacaine (0.5%) , (group C) Ropivacaine (0.5%) with Clonidine (2mcg/kg) before GA. Intra and post-operative hemodynamic responses, fentanyl dosage and the time of rescue analgesia were assessed. Post op pain scores using VAS, nausea, vomiting and sedation were assessed for 24 hours.Results: The mean duration of analgesia is highly significant (p<0.001) in group C. Intra operative fentanyl requirement was significantly lesser in groups B and C (P<0.001). Intra operative hemodynamic changes were significant in Group B and C. Post operative pain scores were significantly lower in groups B and C for the first 24 hours (P<0.001).The time of rescue analgesia in group A was early when compared to group B and C (P<0.001) and in group B when compared to group C .Post operative nausea, vomiting were lower in group B and C. Conclusion: BSCPB performed prior to GA using 0.5% Ropivacaine with or without clonidine was effective in reducing intra and post-operative analgesic requirements. The addition of Clonidine 2mcg/kg had highest analgesic efficacy when compared to Ropivacaine alone.
ABSTRACT
Background: Patients who are candidates for TURP are elderly with cardiovascular and respiratory diseases with anticipated problems during spinal anesthesia. Aim: To compare three different doses (5mg, 7.5mg and 10mg) of Bupivacaine after adding 25 mcg of fentanyl during spinal anesthesia in transurethral resection of prostate surgeries. Methods: Single blinded Randomized clinical study conducted in 75 patients. The subjects were allocated in to three groups. Group A - received Inj. 0.5% Bupivacaine 5 mg, Group B- received Inj. 0.5% Bupivacaine 7.5 mg, Group C - received Inj.0.5% Bupivacaine 10 mg added with 25 mcg of Fentanyl. Baseline and intraoperative vital parameters, time to sensory block at t10, maximum sensory height, time to two segment sensory regression, total duration of sensory blockade, grading of motor blockade and total duration of motor blockade were recorded. Results: Maximum sensory level achieved in Group A was T9, Group B T7 and in Group C it was T5. Time to T10 level in Group A was 7.88 ±0.80 minutes, Group B 5.41 ±0.50 minutes and Group C 3.33 ±0.65 minutes. Two segment sensory regression times in Group A was 56.8±13.61 minutes, Group B 79.58 ±25.32 minutes, and Group C was 116.25 ±9.35 minutes. Total duration of pain free interval in Group A was 84.6 ±20.41 minutes, Group B 104.12 ±45.89 minutes. Group C was 194.20 ±41.53 minutes. Conclusion: Low dose of Bupivacaine (5mg) with addition of Fentanyl 25μg can be used for painless TURP surgeries when compared to higher doses (7.5mg and 10 mg) without any major side effects and facilitates early discharge.